摘要:Epidemiological studies conducted in the past two decades indicate that air pollution causes increase in cardiovascular, breathing and chronic bronchitis disorders and even causes cardiovascular mortality. Therefore, the aim of this study was to investigate the relationship between meteorological parameters, air pollution and cardiovascular mortality in the city of Mashhad in 2014 by a time series model. Data on mortality from cardiovascular disease, meteorological parameters and air pollution in 2014 were gathered from Paradises organization, meteorology organization and pollutant monitoring center, respectively. Then the relationship between these parameters was analyzed using correlation coefficient, generalized linear regression, time series models and comparison of means. The results of the study showed that the highest rate of cardiovascular mortality related to Sulfur dioxide, nitrogen dioxide and then PM2.5. So that each unit increase in SO2, NO2 and PM2.5 pollutants adds to the rate of cardiovascular mortality by 22.5, 2.9 and 0.69, respectively. Pressure, wind speed and rainfall have a significant association with mortality. So that each unit decrease in pressure and wind speed, increases the rate of cardiovascular mortality by 2.79 and 15.77, respectively. It was also found that in the case of one-unit increase in rainfall, the possibility of mortality from the mentioned disease goes up by 3.8 units. It was also found that one-year increase of the age increases the mortality caused by these diseases up to 0.57 percent. Furthermore, the highest rate of cardiovascular mortality related to cold periods of the year. Therefore, considering the growing trend of air pollution and its health effects on human health, performing actions and effective solutions is important in the field of controlling and reducing air pollution in Iranian metropolis including Mashhad.