摘要：Background: In utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life. Objectives: The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort of low-income Latinas living in a California agricultural community. We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age. We also examined the trend with age (2, 3.5, 5, and 7 years) in the exposure–obesity relation. Methods: We included 270 children with o,p´ -DDT, p,p´ -DDT, and p,p´ -DDE concentrations measured in maternal serum during pregnancy (nanograms per gram lipid) and complete 7-year follow-up data including weight (kilograms) and height (centimeters). Body mass index (BMI; kilograms per meter squared) was calculated and obesity was defined as ≥ 95th percentile on the sex-specific BMI-for-age Centers for Disease Control and Prevention 2000 growth charts. Results: At 7 years, 96 (35.6%) children were obese. A 10-fold increase in o,p´ -DDT, p,p´ -DDT, or p,p´ -DDE, was nonsignificantly associated with increased odds (OR) of obesity [ o,p´ -DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p´ -DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p´ -DDE adj-OR = 1.22, 95% CI: 0.72, 2.06]. With increasing age at follow-up, we observed a significant trend toward a positive association between DDT and DDE exposure and odds of obesity. Conclusion: We did not find a significant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children. However, given the observed trend with age, continued follow-up will be informative.
关键词：body mass index; children; dichlorodiphenyltrichloroethane; dichlorodiphenyldichloroethylene; obesity; prenatal exposure
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