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文章基本信息

  • 标题:Hormesis: A Conversation with a Critic
  • 作者:Edward J. Calabrese
  • 期刊名称:Environmental Health Perspectives
  • 印刷版ISSN:0091-6765
  • 电子版ISSN:1552-9924
  • 出版年度:2009
  • 卷号:117
  • 期号:9
  • 页码:1339-1343
  • DOI:10.1289/ehp.0901002
  • 语种:English
  • 出版社:OCR Subscription Services Inc
  • 摘要:Objective In this commentary I respond to points raised in the commentary by Mushak [Ad hoc and fast forward: the science and control of hormesis growth and development. Environ Health Perspect 117:1333–1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology. Discussion In this commentary I demonstrate that Mushak’s analysis contains critical statistical errors and misunderstandings of statistical concepts that invalidate its conclusions concerning the frequency of hormesis in the toxicologic literature. Conclusions In his commentary Mushak offers no significant new conceptual insights, and his key technical criticisms of hormesis frequency findings are unfounded.
  • 关键词:adaptive response; biphasic; dose response; hormesis; hormetic; linear dose response; risk assessment; threshold dose response; U-shaped
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