摘要：To evaluate the role of electrophilicity in the induction of allergic contact dermatitis (ACD) in humans, we compared the structure-activity relationship (SAR) model of ACD with those of electrophilic and nonelectrophilic subsets of chemicals in the ACD database. For these analyses, electrophilicity was defined as the potential of a chemical to induce mutations in Salmonella. It was found that electrophilicity accounted for approximately 30-40% of ACD-inducing ability, and the remainder was associated with nonelectrophilic structures. The identification of these moieties opens the possibility for studying their role in ACD. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (810K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 129 130 131 132
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