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  • 标题:Statistical analysis of data in mutagenicity assays: rodent micronucleus assay.
  • 作者:M Hayashi ; S Hashimoto ; Y Sakamoto
  • 期刊名称:Environmental Health Perspectives
  • 印刷版ISSN:0091-6765
  • 电子版ISSN:1552-9924
  • 出版年度:1994
  • 卷号:102
  • 期号:Suppl 1
  • 页码:49-52
  • 语种:English
  • 出版社:OCR Subscription Services Inc
  • 摘要:To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, has been singled out as the method of choice for the evaluation of mutagenicity assay data, although a number of reports on statistical methods to evaluate such data have been published. Among the mutagenicity assays, the micronucleus assay using mouse bone marrow erythropoietic cells have been widely used to assess cytogenetic activities of test chemicals. A statistical evaluation procedure for this assay is proposed herein, combining the use of historical control data and dose-response relationships. The probability of type I errors and the power of this method are compared with those of some other conventional methods by Monte Carlo simulation. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (538K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 49 50 51 52
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