摘要：Respiratory toxicity of copper was tested in Wistar rats by spraying copper sulfate (330 g/l spray) for daily periods of 1 hr in a self-contained chamber for up to 10 days. The respiratory toxicity was compared with that from intraperitoneal administration of 1 mg Cu/mg body weight and with adequate control rats. Analysis of tissue Cu and Zn was done in lung, liver, kidney, and plasma by using atomic absorption spectrophotometry. Similar organ and subcellular distribution of both elements were found between the two treated groups, and only statistically significant higher levels of Cu were found in plasma and liver. After exposure, Cu and Zn were basically associated with a low-molecular-weight component, which eluted as metallothionein in the postmicrosomal fractions. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (352K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 339 340
Loading...
