摘要：A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (966K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 75 76 77 78 79 80
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