摘要：This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrates that trisomy of chromosome 7 is an early event preceding papilloma formation, and further events, such as mitotic recombination, seem to occur during progression to malignant carcinomas. There is some evidence of a tumor-suppressor locus situated on chromosome 7. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (576K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 41 42 43 44
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