摘要：Classically, immunotoxicology has been defined as the study of adverse effect on the immune system associated with exposure to environmental chemicals, pharmacologic agents, and biologicals. Although a multitude of immune system defects may occur, these can be generally categorized as immunomodulation (immune suppression or potentiation), hypersensitivity (i.e., allergy), and autoimmunity. We present here a brief synopsis of the ontogeny of immunotoxicology as a discipline including methodology currently used in our laboratory, as well as in others, for investigating the immunomodulatory potential of chemicals at the cellular and biochemical level. Additionally, we summarize some studies related to the immunosuppressive effects of one particular compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Last we discuss potential future directions and challenges in the field of immunotoxicology. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 157 158 159 160 161 162
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