首页    期刊浏览 2024年11月25日 星期一
登录注册

文章基本信息

  • 标题:Chemotherapy-induced immunosuppression.
  • 作者:L Rasmussen ; A Arvin
  • 期刊名称:Environmental Health Perspectives
  • 印刷版ISSN:0091-6765
  • 电子版ISSN:1552-9924
  • 出版年度:1982
  • 卷号:43
  • 页码:21
  • 语种:English
  • 出版社:OCR Subscription Services Inc
  • 摘要:Chemotherapeutic agents are used widely in clinical medicine for the treatment of conditions where diminution of the host immune response is a goal. The clinical use of immunosuppression is indicated for immunologically mediated disease, lymphoproliferative diseases, and prevention of graft rejection. Five categories of agents are useful for these purposes; they are ionizing irradiation, corticosteroids, biological alkylating agents, antilymphocyte sera and antimetabolites. While the specific molecular action of many of these drugs is known, how they affect cellular events in immune responses is less clear. One of the unfortunate sequelae of chemotherapy induced immunosuppression is an increased susceptibility of the host to opportunistic pathogens or malignancies. Specific methods are described for monitoring the various parameters of both humoral and cellular immunity. Studies of immunologic function in lymphoma patients and cardiac transplant patients treated with immunosuppressive drugs have shown specific defects in cell mediated immunity to herpes viruses which may relate to their increased susceptibility to infection by these agents. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (673K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 21 22 23 24 25
Loading...
联系我们|关于我们|网站声明
国家哲学社会科学文献中心版权所有