摘要：The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (650K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 23 24 25 26 27
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