摘要：Fundamental differences in dose--response relationships between "stochastic" and "nonstochastic" effects of chemicals are identified and discussed. The difficulties in extrapolating into the low-dose region of dose--response curves are pointed out. In some instances of nonstochastic effects, observations concerning interindividual variability in biological half-time and threshold body burden for symptoms may be used for such extrapolation. An example based on data from the literature concerning effects of methyl-mercury on the nervous system is given. The confidence intervals of the extrapolated risk-values are computed and discussed in relation to assumptions concerning the mathematical model to be used in the extrapolation process. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (792K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 97 98 99 100 101 102
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