Even if global warming is kept below +2°C, European agriculture will be significantly impacted. Soil degradation may amplify these impacts substantially and thus hamper crop production further. We quantify biophysical consequences and bracket uncertainty of +2°C warming on calories supply from 10 major crops and vulnerability to soil degradation in Europe using crop modeling. The Environmental Policy Integrated Climate (EPIC) model together with regional climate projections from the European branch of the Coordinated Regional Downscaling Experiment (EURO‐CORDEX) was used for this purpose. A robustly positive calorie yield change was estimated for the EU Member States except for some regions in Southern and South‐Eastern Europe. The mean impacts range from +30 Gcal ha⁻¹ in the north, through +25 and +20 Gcal ha⁻¹ in Western and Eastern Europe, respectively, to +10 Gcal ha⁻¹ in the south if soil degradation and heat impacts are not accounted for. Elevated CO₂ and increased temperature are the dominant drivers of the simulated yield changes in high‐input agricultural systems. The growth stimulus due to elevated CO₂ may offset potentially negative yield impacts of temperature increase by +2°C in most of Europe. Soil degradation causes a calorie vulnerability ranging from 0 to 50 Gcal ha⁻¹ due to insufficient compensation for nutrient depletion and this might undermine climate benefits in many regions, if not prevented by adaptation measures, especially in Eastern and North‐Eastern Europe. Uncertainties due to future potentials for crop intensification are about 2–50 times higher than climate change impacts.