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  • 标题:Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum
  • 本地全文:下载
  • 作者:Daiki Kawashima ; Tsuyoshi Hosoya ; Hiroshi Tomoda
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2018
  • 卷号:66
  • 期号:8
  • 页码:826-829
  • DOI:10.1248/cpb.c18-00264
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Three new compounds, sydowianumols A ( 1 ), B ( 2 ), and C ( 3 ), were isolated from culture broth and mycelial extracts of Poculum pseudosydowianum (TNS-F-57853), an endophytic fungus isolated from fresh leaves of Quercus crispula . The structures of new compounds 1 – 3 were elucidated from spectroscopic data. Sydowianumols A ( 1 ) and B ( 2 ) exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with 90% minimum inhibitory concentration (MIC90) values of 12.5 µg/mL.
  • 关键词:Poculum pseudosydowianum;endophytic fungus;Quercus crispula;sydowianumol;antimicrobial activity;methicillin-resistant Staphylococcus aureus (MRSA)
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