The relationships between gratitude, satisfaction with life, and stress have been widely examined in different cultures. However, empirical research on these variables is scant in Saudi Arabia. The aim of this study was to investigate the mediation effect of stress in the relationship between gratitude and life satisfaction in an understudied population of Arabic student sample. Participants were 141 Arabic-speaking undergraduate students (18 males and 123 females; mean age = 23.8 years, SD = 4.23) and completed self-report measures of gratitude, satisfaction with life, and stress. As expected, regression analysis showed that gratitude positively predicted satisfaction with life, while stress negatively predicted satisfaction with life. Mediation analysis showed that stress fully mediate the relationship between gratitude and life satisfaction. Higher levels of gratitude positively predicted higher levels of satisfaction with life though the decreased stress. The emerging results have important implications to research and practice regarding understanding the mechanism underlying gratitude, satisfaction with life, and stress in the context of a non-western country.