摘要：In order to examine the hypothesis that the treatment of TNF-α can impose inflammation and endoplasmic reticulum (ER) stress in hepatic cells, and that quercetin has a defensive effect against TNF-α-induced ER stress and insulin resistance, we evaluated the effect of quercetin (3 µg/mL and 5 µg/mL) in the TNF-α-induced HepG2 cells. The TNF-α-stimulated control group caused a marked increase in the activation of inflammation and ER stress response. Quercetin, however, caused the interruption of TNF-α-induced inflammation and ER stress. In addition, the treatment of quercetin resulted in significant decreases in serine phosphorylation of IRS-1, phosphorylation of JNK, and the expression of gluconeogenic genes compared with the TNF-α-stimulated control group. In conclusion, we suggest that quercetin can protect hepatic insulin resistance by exerting a protective effect against the ER stress and inflammation induced by TNF-α.
关键词：quercetin; TNF-α; ER stress; insulin resistance; inflammation
