标题：A descriptive study to assess the drug sensitivity pattern to antitubercular drugs in patients visiting department of respiratory medicine at a tertiary care hospital at Western Maharashtra
摘要：Objective/Introduction: Tuberculosis is a overwhelming public health worry in India. The Indian Subcontinent accounts for about 25% of the TB burden worldwide. Across the world, India has the highest burden of both TB and MDR-TB. The aim of this study was to study the resistance pattern of Mycobacterium Tuberculosis to first and second line anti-TB drugs among specimens from a hospital in Tertiary Care Hospital in Western Maharashtra. Materials and Method: This record based study was conducted at Tertiary Care Hospital in Western Maharashtra, from January 2017 .Records of Sputum from 2013 to 2017 were obtained from patients with suspected TB. Drug-sensitivity testing was performed by the Mycobacteria Growth Indicator Tube (MGIT) method. Sensitivity to First line and second line drugs and Quinolones were tested. Results: Among 734 patients, 701(95.5%) were males and 33(4.5%) were females. Analysis of our Study result showed that 21.7% of patients were mono-drug resistant. Out of 734 isolates, 56 (7.62 %) showed multi-drug resistance (resistance to INH and RIF at least) and 33 out of 734 (4.5%) whereas 39 (5.6%) out of the 734 samples showed XDR. Conclusion:This study confirms that drug resistance, including MDR, observed against all first-line TB drugs was a real threat in the management of TB infection. The patterns of resistance in this study will assist clinicians in providing the right treatment regimen to TB patients and bring about an improvement in their clinical condition.
