标题：Long-term efficacy of single-dose mass treatment with diethylcarbamazine citrate against diurnally subperiodic Wuchereria bancrofti: eight years' experience in Samoa.
摘要：A single-dose of diethylcarbamazine citrate (DEC, 6 mg per kg body weight) was administered in three mass treatment campaigns to > 80% of the estimated total Samoan population (160,000) in 1982, 1983, and 1986. The effect of the drug was evaluated before and after each campaign by conducting four blood surveys covering 9600 to 13,700 people from 26-34 villages on each occasion. The drug reduced the prevalence of Wuchereria bancrofti microfilariae from 5.6% to 2.5% (a 55% reduction), while the transmission potential (the estimated mosquito infection rate if everyone is equally exposed to mosquito bites) dropped from 2.18 to 0.67 (a 70% reduction). The total number of microfilariae in the Samoan population is estimated to have been reduced by 80%. A spaced, single-dose treatment with DEC at a 1-2-year interval therefore seems to be an effective control measure against diurnally subperiodic W. bancrofti. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1023K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 769 770 771 772 773 774 775 776
