摘要：The thymidine kinase produced in cell cultures by several orthopoxviruses has been tested for sensitivity to inhibition by thymidine triphosphate (TTP). Thymidine kinase preparations from eleven variola isolates and from five “whitepox” isolates were all found to be sensitive to inhibition by TTP. Preparations from other orthopoxviruses, including vaccinia, cowpox, and monkeypox, were all resistant to inhibition by TTP. There was no overlap between the two groups of results and no viruses were found which gave intermediate results. Tests with hybrid viruses showed that this character segregated independently of other biological marker characters and is thus a valuable additional marker for variola and variola-related viruses. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (500K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 377 378 379 380
