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  • 标题:Attenuated recombinant strains of Vibrio cholerae for oral immunization
  • 作者:Brahm S. Srivastava ; V. B. Sinha ; Ranjana Srivastava
  • 期刊名称:Bulletin of the World Health Organization
  • 印刷版ISSN:0042-9686
  • 出版年度:1979
  • 卷号:57
  • 期号:4
  • 页码:649-654
  • 语种:English
  • 出版社:World Health Organisation
  • 摘要:Two attenuated strains of Vibrio cholerae, CD1 and CD3, have been isolated that have remained stable since 1976. These strains are motile, adhere to and multiply in rabbit intestine, and colonize the gut of infant mice for 6-7 days. Both strains are antigenic and provide protection to challenge in the mouse protection test and in the rabbit ileal loop model. Because of their ability to adhere to and colonize the gut, and since they are antigenic, strains CD1 and CD3 have the potentiality of oral vaccines. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (770K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 649 650 651 652 653 654
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