标题：Recent developments in the assessment of the immune response to malaria, especially as related to vaccination: Immunity to Plasmodium yoelii and Babesia microti: modulation by the CBA/N X-chromosome
摘要：CBA/N mice carry an X-linked recessive defect expressed in cells of the B cell lineage. The major deficiency in these mice is an almost complete inability to respond to certain thymus-independent antigens, such as pneumococcal polysaccharide type III (S III). We have examined the responses of mice carrying the CBA/N X-chromosome to the malaria parasite Plasmodium yoelii and the piroplasm Babesia microti. We have found that the duration and severity of these infections is increased in mice carrying the CBA/N X-chromosome and that this is associated with a markedly defective IgM antibody response to the parasitized red cell and a failure to produce autoantibodies to bromelain-treated mouse RBCs. An autoimmune response directed at modified determinants on the red cell membrane may be one of the factors involved in the control of these infections. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (617K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 255 256 257 258 259
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