摘要：A test for monkeypox-specific antibodies is described. Monkeypox immune sera can be made type-specific by immunoabsorption with heterotypic poxvirus extracts. Monkeypox-specific antibodies were demonstrated in sera from 9 cynomolgus monkeys ( Macaca fascicularis ) that had previously been experimentally infected with monkeypox. Monkeypox-specific antibodies were found in 3 wild-caught African monkeys ( Cercopithecus spp.) and in 3 human sera collected from Africans in the Ivory Coast and Nigeria 3½-4 years after they had suffered a pox-like infection. Monkeypox had been recognized in one of the patients by virus isolation, and had been suspected in the others for epidemiological reasons. Vaccinia-specific antibodies were found in 4 human sera collected 6 weeks after smallpox vaccination. The serological results provide the first laboratory evidence of a monkeypox reservoir in wild monkeys. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (634K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 355 356 357 358 359 360
