摘要：In previously published studies, a number of BCG strains used in several production laboratories were compared in animal models. Liquid vaccines from the different strains were prepared in one laboratory with a uniform technique, the aim being to obtain uniform in vitro properties. In the studies reported here, such vaccines were compared by means of vaccinating children in India and Denmark and then measuring their post-vaccination skin lesions and tuberculin sensitivity. One strain induced delayed hypersensitivity strikingly weaker than that induced by any of the others, although the vaccine was in no way inferior in terms of exhaustive in vitro tests. Differences among the other strains were slight, although sometimes statistically significant. The implications of such differences are discussed. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (727K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 489 490 491 492 493 494
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