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  • 标题:Simplification of isoniazid phenotyping procedure to promote its application in the chemotherapy of tuberculosis
  • 作者:L. Eidus ; P. Varughese ; M. M. Hodgkin
  • 期刊名称:Bulletin of the World Health Organization
  • 印刷版ISSN:0042-9686
  • 出版年度:1973
  • 卷号:49
  • 期号:5
  • 页码:507-516
  • 语种:English
  • 出版社:World Health Organisation
  • 摘要:In this investigation a simple urine test for phenotyping isoniazid inactivators is evaluated. In the new method, isoniazid is artificially acetylated in urine and determined by the same colour reaction as that used for acetylisoniazid. Comparative studies showed that the test is reliable and can be performed with accuracy and ease even in poorly equipped laboratories. In contrast to other urine tests, it does not require an expensive spectrophotometer, tedious hydrolysis processing of the samples, or standard curves. The results can be read on a plain colorimeter, or even without any instrument. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 507 508 509 510 511 512 513 514 515 516
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