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  • 标题:Studies on the prophylactic and radical curative activity of RC-12 against Plasmodium cynomolgi in Macaca mulatta
  • 作者:Thomas M. Sodeman ; Peter G. Contacos ; William E. Collins
  • 期刊名称:Bulletin of the World Health Organization
  • 印刷版ISSN:0042-9686
  • 出版年度:1972
  • 卷号:47
  • 期号:3
  • 页码:425-428
  • 语种:English
  • 出版社:World Health Organisation
  • 摘要:The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of EE stages. The usefulness of RC-12 for effecting radical cures is, however, still open to doubt. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (524K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 425 426 427 428
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