标题：Session I—The Inhibition of Esterases by Organophosphorus Compounds and Carbamates: Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors
摘要：This paper discusses the relation between chemical structure and inactivation of the enzyme acetylcholinesterase (AChE) by organophosphorus esters, in terms of reactivity and steric effects. The discussion is centered in organophosphorus esters of the type (R) (R′) P(O) X, where X is a readily displaceable group and R and R′ are various combinations of alkyl, alkoxy, alkylthio, and amido moieties. Specific examples illustrating the effect of AChE inhibition on the selective toxicity of organophosphorus esters for insects and mammals are also presented. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 31 32 33 34 35 36 37 38 39 40 41 42
