摘要：The sensitivity of Plasmodium falciparum to antimalarial drugs is primarily determined by observing changes in the level of parasitaemia after administration of drugs to man. Performance of such a study and interpretation of its results may present certain difficulties, especially when conducted among persons living in malarious areas. The present study was conducted to evaluate the usefulness of a simple in vitro method for detecting chloroquine-resistant strains among infected residents of Mato Grosso, Brazil. The findings indicated the participants were infected with chloroquine-resistant P. falciparum. Subsequent administration of a standard regimen of chloroquine (25 mg/kg) to these subjects confirmed the findings observed in vitro by failing to cure 28 out of 30 infections. This in vitro technique seems to provide a useful method of determining the presence or prevalence of chloroquine-resistant strains in a given area. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 157 158 159 160 161 162 163 164 165 166 167
