标题：A serological survey for cholera antibodies in rural East Pakistan: 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera*
摘要：Controlled cholera vaccine field trials were held in Matlab Bazar in rural East Pakistan in 1963 and 1964. In July—September 1965, a serological survey for cholera antibodies was carried out on a random sample of the field-trial population. Results are given for the control group only, as representative of the pattern found in an endemic cholera area. Only 2% of the blood samples from children under 10 years of age were found to have detectable agglutinating antibody (titres of 1:20 or more), while the proportion in the age-group over 30 years was 27%-30%. Tests for vibriocidal antibody showed that none of the blood samples from children under 1 year of age contained detectable antibody, while 87%-90% of those from adults over 30 years did so. The rise in the geometric mean vibriocidal titre showed an almost linear correlation with a sharp fall in the cholera case rate with age. Since a similar survey in a non-endemic area (Czechoslovakia) did not reveal any rise in antibody titre with age, and since cholera epidemics in areas without recent experience of the disease are characterized by a higher incidence rate in adults than in children, it is suggested that the antibody titres give a measure of the level of immunity in a population. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (924K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 327 328 329 330 331 332 333 334
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