摘要：Gross deterioration of cycloserine during transit and storage in the tropics is reported from the Tuberculosis Chemotherapy Centre, Madras. Laboratory experiments suggest that high humidity, rather than high temperature, is the main cause of the deterioration. Further investigations undertaken at the Centre indicate that deterioration can be prevented by storing the drug in tightly closed glass bottles in an air-conditioned room (18°C); if such facilities are not available, and the drug has to be stored at ambient temperature and humidity, the use of air-tight polyethylene bottles will serve to delay the deterioration. The findings also suggest that, when cycloserine is dispensed to patients, individual doses should be heat-sealed in polyethylene strips and that not more than a week's supply should be given at any one time. The authors discuss various measures that could be employed by manufacturers and by shipping and clearing agents to minimize the possibility of deterioration. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 781 782 783 784 785 786 787 788 789
