摘要：As knowledge of the epidemiology of tuberculosis in Greenland has increased, it has become evident that the majority of cases develop long after the primary infection and that it would therefore be valuable from the public health point of view if the disease rate among naturally infected persons could be reduced. To examine the possibility of achieving this, a double-blind drug trial with isoniazid and a placebo was conducted among some 70% of the adult population of western Greenland. The results show that throughout the six years of the study the incidence of tuberculosis was lower in the group treated with isoniazid and that this reduction occurred whether the initial X-rays pictures were normal or showed suspicious or healed lesions. It is concluded that chemoprophylaxis programmes should probably be administered only to selected groups of the population. The delimitation of such groups is discussed on the basis of their tuberculosis risk and of the expected yield in terms of reduction in tuberculosis prevalence. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526
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