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  • 标题:Potentiation of activity of diaphenylsulfone and pyrimethamine against Plasmodium gallinaceum and Plasmodium cynomolgi bastianellii
  • 本地全文:下载
  • 作者:P. C. Basu ; N. N. Singh ; Naunihal Singh
  • 期刊名称:Bulletin of the World Health Organization
  • 印刷版ISSN:0042-9686
  • 出版年度:1964
  • 卷号:31
  • 期号:5
  • 页码:699-705
  • 语种:English
  • 出版社:World Health Organisation
  • 摘要:In view of the fact that diaphenylsulfone has been shown to have low schizontocidal activity against Plasmodium gallinaceum and to lead to resistance in strains of P. cynomolgi, investigations were undertaken into the joint action of diaphenylsulfone and pyrimethamine against P. gallinaceum in chicks and P. cynomolgi bastianellii in monkeys. These drugs were assayed separately and in various combinations. It was found that at certain dose levels combination of the two drugs led to potentiation of their plasmocidal activity. On the other hand, this synergistic effect was not noted with combinations containing lower dosages of either drug; with these, a simple additive effect occurred. The authors suggest that the two drugs probably act on the same metabolic pathway but that their points of attack may be different. They note also that there was a difference in the response of P. gallinaceum in chicks and of P. cynomolgi bastianellii in monkeys to the combined use of the two drugs. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (710K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 699 700 701 702 703 704 705
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