标题：Yellow fever vaccination in Malaya by subcutaneous injection and multiple puncture: Haemagglutinin-inhibiting antibody responses in persons with and without pre-existing antibody
摘要：In view of the risk of introduction of yellow fever into South-East Asia, comparative studies have been made of yellow fever vaccination in Malayan volunteers with a high prevalence of antibody to related viruses and in volunteers without related antibody. In a previous paper the neutralizing antibody responses of these volunteers were reported. The present paper describes the haemagglutinin-inhibiting (HI) antibody responses of the same groups of volunteers and discusses the relationship of these responses to the neutralizing antibody responses. The HI responses to yellow fever following vaccination closely paralleled the neutralizing antibody responses whether vaccination was subcutaneous or by multiple puncture. Volunteers with a high level of YF HI antibody due to infection with other group B viruses were found to be less likely to show a significant YF HI response than those without antibody. 90% of HI responses could be detected by the 21st day after vaccination. As with neutralizing antibody responses, volunteers given vaccine doses of 50-500 mouse intracerebral LD50 subcutaneously gave greater responses than those given higher doses. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (652K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 75 76 77 78 79 80
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