标题：Duration of immunity to reinfection in guinea-pigs treated with antirabies serum and vaccine, and the value of booster doses of vaccine in re-treatment
摘要：Studies undertaken to determine the resistance of guinea-pigs which have survived a moderate challenge as a result of treatment with serum and vaccine to subsequent severe challenges with homologous and heterologous strains of rabies street virus have shown that, even with large groups of animals, treatment with serum and vaccine saved nearly 70% of the animals against challenges of about 100 LD50. The animals which survived such treatment and challenge continued to have a considerable degree of immunity to rechallenge even 15 months after the first treatment. There was no advantage in giving two booster doses of vaccine during this period. The immune status of rechallenged guinea-pigs seemed to depend primarily on the original treatment rather than on the strain of virus used for the first challenge. Guinea-pigs which survived an earlier challenge as a result of treatment fared better against the later challenge than fresh groups of treated but not challenged animals given the same challenge. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (522K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 511 512 513 514
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