摘要：In view of earlier work which suggested that certain derivatives of isatin β-thiosemicarbazone might be of possible clinical use in smallpox infections, several such derivatives have been tested for antiviral effect in infant mice inoculated intracerebrally with up to 103 LD50 (up to 106.5 pock-forming units) of the Harvey strain of variola major virus. Survival of 100% was obtained in mice treated twice daily with N-methylisatin β-thiosemicarbazone in a dose level of 10 mg/kg, isatin β-thiosemicarbazone in a dose level of 25 mg/kg and 7-methylisation β-thiosemicarbazone at 10 mg/kg, the treatment beginning immediately after infection. No evidence of toxicity was observed at these dose levels. At lower dose levels of these and other related compounds complete protection was not obtained, but a chemotherapeutic effect was demonstrated by a prolongation of the mean survival time. Mice which had survived variola infection after treatment with an adequate dose of chemotherapeutic agent were immune when challenged with 105 pock-forming units of rabbitpox virus. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (696K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 727 728 729 730 731 732
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