标题：Relationship between pock counts on the chorio-allantoic membrane and percentages of ”takes” in primary vaccination of human beings with two smallpox vaccines
摘要：In view of doubts as to the potency level required to obtain nearly 100% successful vaccinations with the glycerolated smallpox vaccine prepared by the Netherlands National Institute of Public Health, its dose-effect relationship was compared with that of a glycerolated lymph from the Lister Institute of Preventive Medicine, England. The potency was estimated from pock counts on the chorio-allantoic membrane of chick embryos and the effect was judged from the ”take” rate obtained in the primary vaccination of soldiers, the data being subjected to probit analysis. The relationship observed between the number of pock-forming units and the percentage of successful primary vaccinations was nearly identical with the two vaccines. The 50% effective doses were found to be 1.3-1.4 × 106 PFU/ml and the 99% doses to be 4.1-4.3 × 107 PFU/ml. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (780K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 311 312 313 314 315 316
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