摘要：The use of mice for the assay of tetanus toxoids would offer considerable advantages over the use of guinea-pigs, but mice cannot readily be immunized with the fluid tetanus toxoid at present designated as the International Standard. This study shows, however, that the mouse is a very suitable laboratory animal for the comparison of adsorbed tetanus toxoids, and that an AlPO4-adsorbed vaccine, which is stable at 4°C, is a satisfactory reference preparation. The log-dose-response lines of toxoids adsorbed on different quantities of AlPO4 and on various quantities of another adsorbent ran parallel to those of the reference vaccine. The 95% confidence limits for the potencies of tetanus vaccines, diphtheria-tetanus vaccines, and diphtheria-pertussis-tetanus vaccines, determined by assay against the reference vaccine in mice, showed a high degree of reproducibility of the results. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 1133 1134 1135 1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150
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