摘要：In a vaccination and laboratory study, two dried smallpox vaccines (designated P and Q) were tested at intervals of 4, 8, 16, and 32 weeks after storage at both 37°C and 45°C. Vaccine P was also tested after 64 weeks at these temperatures and gave 100% successful vaccination rates after all periods of storage at both temperatures. Vaccine Q deteriorated within four weeks, rapidly at 45°C and less rapidly, but very substantially, at 37°C. There was no clear evidence of the cause of this deterioration, but there was a suggestion of denaturation of some of the samples stored at the higher temperature. So far as could be ascertained, the laboratory results—rabbit skin scarification tests and chorio-allantoic membrane pock counts—ran parallel with the vaccination success rates. The pock count was found to be the more accurate method of laboratory titration. Vaccine P as used in the trial was not an exceptional batch. Vaccines which give a pock count of 108 infective units per ml will give the highest possible rate of successful primary vaccinations. A statistical note on the trials is given in an annex. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77
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