摘要：This paper reports two studies dealing with the effect of light on the potency of tuberculin. In each study light-exposed and unexposed (control) samples from the same tuberculin dilution were compared by duplicate intradermal Mantoux testing in groups of BCG-vaccinated schoolchildren. The difference in mean size between the children's reactions to the two samples was used as a measure of the light-effect. In the first study, carried out in Egypt, a 5 TU dilution was exposed in ordinary, clear, glass bottles to subtropical sunlight for a total of 12 hours. Duplicate testing in 154 children showed that the exposed dilution had lost all but a fraction of its original potency. To obtain information on the relative effect of different parts of the solar spectrum 10 TU dilutions were irradiated with artificial light of different wave-lengths in a second study comprising 727 children. Ultra-violet radiation was found to have a strong effect on the potency of tuberculin whereas medium- and long-wave radiation of the same intensity had little or no effect. It is of practical importance that ultra-violet rays of the wave-lengths used in this study are transmitted by ordinary clear glass. From the reported studies it seems that prolonged exposure of tuberculin to strong sunlight and daylight should be avoided. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (969K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 179 180 181 182 183 184 185 186 187 188
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