期刊名称：Indian Journal of Bioinformatics and Biotechnology
印刷版ISSN：2319-6580
电子版ISSN：2319-6599
出版年度：2018
卷号：6
期号：6
页码：1-6
语种：English
出版社：Indian Society for Education and Environment
摘要：Objective : To find digestive enzyme inhibitors as the therapeutic approach to deal with the management of diabetes mellitus. Methods : In this study, we had in silico, analysed the anti-diabetic activity of the commercially available drugs used for diabetes treatment and few compounds which may have a potential to treat the disease. The main studied compounds are miglitol, voglibose, metformin, acetohexamide, squalene, stearic acid, heptacosanol, stigmasterol. The compounds were predicted for their biological properties based on their chemical structures as well as drug like activities. The compounds were docked with the digestive enzyme α- amylase and hydrogen bondings were revealed to study the relative stability of the complexes, which may result in the enzyme inhibition. Findings : It may be concluded that if we succeed in achieving enzyme inhibition by a compound, then the compound may prevent the breakdown of carbohydrates into glucose in the body, thus maintaining the appropriate blood glucose levels. Application : Compounds acting as digestive enzyme inhibitors could help in control of diabetes mellitus by delaying the release of post-prandial glucose level in the blood.
