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  • 标题:The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites
  • 作者:Matthias Quick ; Ara M. Abramyan ; Pattama Wiriyasermkul
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2018
  • 卷号:115
  • 期号:34
  • 页码:E7924-E7931
  • DOI:10.1073/pnas.1717444115
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Crystal structures of the neurotransmitter:sodium symporter MhsT revealed occluded inward-facing states with one substrate (Trp) bound in the primary substrate (S1) site and a collapsed extracellular vestibule, which in LeuT contains the second substrate (S2) site. In n -dodecyl-β-
  • 关键词:membrane transport ; neurotransmitter:sodium symporter ; LeuT fold ; MhsT
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