摘要：Background/Aim: The present study investigates the effect of daily green-plant membrane (thylakoid) supplementation for two months on body weight, body composition, metabolic profile and rating of appetite sensations in overweight women on a restricted diet. Methods: 26 women, Body Mass Index (BMI) 27.5 ± 1.9, randomized into a thylakoid (n=12) and control group (n=14), followed a 7500 kJ/day diet with or without 5.6 g of thylakoids supplemented in a blueberry drink, and exercised 60 minutes per day. Fasting blood samples were taken with two weeks interval. On the first and last day of the study subjects answered Visual Analogue Scale (VAS) questions regarding hunger and cravings. Results: Both control and thylakoid-treated groups lost body weight and body fat over the course of the study, but no differences were found between the groups. Thylakoid supplementation resulted in decreased hunger (p=0.016) and decreased urge for chocolate (p=0.052) in contrast to the control group. Leptin levels were significantly reduced at the end of the study in the thylakoid-treated group (p=0.012) compared to control, suggesting a decreased fat mass. The overall metabolic profile was also improved in the treated group compared to controls, based on body weight, waist and hip-circumference, trunk and total body fat, p-leptin, p-LDL, p-ApoB1, ptotal cholesterol, p-TAG, blood glucose, p-HbA1C and p-insulin (p=0.024). Conclusions: Thylakoids added to food in adjunct to lifestyle intervention may be helpful in enabling overweight subjects to lose weight by suppression of hedonic hunger.
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