摘要：Purpose: Since endothelial dysfunction candevelop early in the adulthood, the purpose of thestudy was to determine how serum lipids, bodymeasures and dietary habits affect serum markers ofvascular activation in young women.Materials and methods: Twenty five healthywomen, aged 19-22 years, were enrolled in thestudy. Serum lipids profile (total cholesterol, HDLcholesterol,triglycerides) was assayed withlaboratory test kits. Concentrations of sICAM-1,sVCAM-1 and E-selectin were determined with theELISA technique. Anthropometric measurementswere taken including skinfold thickness and waistcircumference. Food consumption data werecollected using 3 repeats of 24-hour dietary recalls.Dietary habits of the women were assessed with a9-point alternate Mediterranean Diet score (aMED).Results: Sixty eight percent of the subjects hadtheir HDL-cholesterol levels below the desirableconcentration, 20% had LDL-cholesterol elevated,and 32% demonstrated increased totaltriacylglycerols (TAG). The levels of serum TAG>199 mg/dL were associated with a significant risein the VCAM-1 concentration. Dietary wholegrainproducts seem to reduce the serum E-selectin.Conclusions: The results suggest that youngwomen of normal body mass, but demonstratingincreased levels of serum TAG, may be at risk ofdeveloping endothelial dysfunction. Animplementation of the wholegrain productsconsumption into their dietary practices wouldpossibly be of health benefit.
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