摘要：Introduction: Whipple’s disease is a chronicsystemic infectious disorder with Tropherymawhipplei as an etiologic agent, occurring rarely andaffecting numerous organs and systems. The varietyof symptoms and a non-typical course make itdifficult to establish a proper diagnosis.Purpose: In this study, etiopathogenesis,diagnostics and treatment of Whipple’s diseasewere presented based on the case report of 60-yearoldman diagnosed with Whipple’s disease.Case presentation: Persistent diarrhoea withweight loss, lymphadenopathy in the abdominalcavity and moderate microcytic anemiapredominated in the clinical picture. Diagnosis wasput based on the clinical picture and macroscopicassessment of the small intestine and the presenceof macrophages filled with a PAS-positivesubstance in the lamina propria. To deependiagnostics, samples collected were assessedshowing macrophages with the damaged mucosa,containing numerous elongated micro-organismswhose ultrastructure corresponded to Tropherymawhipplei. The patient’s clinical conditions improvedafter antibiotic therapy.Conclusions: It is vital to remember aboutWhipple’s disease in patients with chronic diseasesdue to a non-specific clinical picture and difficultiesin establishing a proper diagnosis. When the diseaseis diagnosed unequivocally, proper and effectiveantibiotic therapy should be instituted immediately.
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