In order to evaluate the effect of irrigation water salinity in interaction with different potassium and calcium ratios applied through fertigation in eggplant, an experiment was carried out at the Department of Environmental and Technological Sciences of the Federal Rural University of the Semi-Arid Region, in Mossoró, RN, Brazil. The experimental design was randomized blocks, in a 5 x 4 factorial scheme, with four replicates. The treatments were obtained by the combination between five ionic ratios of potassium and calcium (F1 = 4.2/1; F2 = 3.5/1; F3 = 2.8/1; F4 = 2.2/1; F5 = 1.8/1) and four levels of irrigation water salinity (S1 – 0.5; S2 – 2.0; S3 – 3.5; and S4 – 5.0 dS m-1). The following variables were evaluated: number of fruits per plant, fruit length, fruit diameter, fruit fresh weight and yield. Yield, fruit length, fruit fresh weight and number of fruits decreased with the increase of salinity in all the treatments. Salinity significantly affected fruit diameter, which increased only under fertigation with potassium-rich solutions.