期刊名称：Journal of Advanced Veterinary and Animal Research
印刷版ISSN：2311-7710
出版年度：2018
卷号：5
期号：3
页码：275-281
DOI：10.5455/javar.2018.e276
出版社：Bangladesh Agricultural University, Faculty of Veterinary Science
摘要：Objective: This study was carried out to evaluate the effect of garlic ( Allium sativum ) with its immunomodulatory activity, on the susceptibility of broilers to infectious bursal disease, being an immunosuppressive disease. Materials and methods : Day-old broilers (102) were separated into 6 groups A-F of 17 each. Groups A, B and C had 0.125% of garlic-meal in feed. At 8 and 18 days of age groups A, C, D and F were administered IBD vaccine and groups B, C, D and E were infected with 1LD50 IBD virus (10-3.4 in 0.08ml PBS) via conjuctival instillation at 4 week-old. Clinical signs, mortality and gross pathological lesions were scored. Histopathological lesions in bursae of Fabricius were recorded. Virus antibody titre in serum was assayed at 1 day-old, 4 and 6 weeks-old using quantitative agar gel immunodiffusion test. Data generated was analysed using descriptive statistics, ANOVA and Duncan’s multiple comparison tests ( P<0.05 ). Results: The two infected garlic groups B (non-vaccinated) and C (vaccinated) had lower scores for clinical signs (23 and 12 points, respectively) but higher mortality rates (30% and 25%, respectively) than their no-garlic controls (E; 27 points, 11.8% and D; 21 points, 0%, respectively). However, vaccinal antibody response at 6 week-old, was significantly higher in garlic group A (2.8±0.8) than in no-garlic group F (1.8±1.8) in the absence of infection. Conclusion: A more acute outcome of IBD virus infection was observed in garlic-fed broilers, which was ameliorated in vaccinated broilers, however, antibody response to vaccination was enhanced in the absence of infection. http://doi.org/10.5455/javar.2018.e276
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