摘要：Background: It has been suggested that children who are exposed to agricultural pesticides have an increased
risk of asthma, but evidence for associations betweeen residential pesticide exposure and childhood asthma is
inconsistent.
Objectives: To investigate the associations of residential pesticide exposure with the prevalence of asthma and
related symptoms within a Dutch birth cohort study.
Methods: In this cross-sectional analysis, we included participants of the PIAMA birth cohort study with data on
residential pesticide exposure and asthma from parent-completed questionnaires at age 14, collected in 2012
(N = 1473). We used spatial data on the presence of individual crops (cereals, open field vegetables, commercial
crops, open field floriculture/bulbs, corn and potatoes) and pesticide application on these crops to estimate
residential exposure to pesticides with known irritant properties for the respiratory system within distances of
100, 500, and 1000 m of the participants' homes. Logistic regression was used to estimate associations between
exposure and outcomes, adjusting for potential confounders.
Results: No associations were found between living within 100, 500 and 1000 m of agricultural fields likely
treated with pesticides and symptoms of asthma. For instance, for participants living within 100 m of fields with
any crops likely treated with pesticides, the adjusted odds ratios (95% confidence interval) for the prevalence of
asthma, shortness of breath and dry night cough at age 14 were 0.31 (0.07, 1.32), 0.61 (0.23, 1.57) and 1.26
(0.56, 2.80), respectively. No associations were found between estimated exposure to pesticides with known
irritant properties for the respiratory system and asthma or related symptoms.
Conclusions: There was no association between living near agricultural fields likely treated with pesticides and
asthma and related respiratory symptoms, among our study participants.
