摘要：After randomized trials failed to support the use of hormone replacement therapy (HRT) for preventing cardiovascular disease (CVD), HRT use for postmenopausal women declined. Our analysis of 1999–2000 and 2003–2004 National Health and Nutrition Surveys (NHANES) shows that HRT use decreased 19% (from 27.6 to 8.4%; P < .001) among women with CVD versus 3% (from 19.8 to 16.8%; P = .68) among low-risk women, suggesting that most of the drop in HRT use may be among women prescribed HRT as an unproven treatment to prevent CVD. In the early 1990s, on the basis of findings from observational studies, hormone replacement therapy (HRT) was widely promoted to decrease cardiovascular disease (CVD) in postmenopausal women. 1 , 2 Subsequently, large randomized trials found that HRT did not prevent CVD and that, instead, HRT was associated with an increased risk for stroke and combined estrogen-progestin HRT was associated with a possible increased risk for heart disease. 3 – 6 Following broad dissemination of these results, 7 , 8 HRT use declined markedly. 1 , 9 We report on HRT use in the years 1999–2000 and 2003–2004 by CVD risk, socioeconomic status, and race/ethnicity. We hypothesized that reductions in HRT would be greatest among women with CVD or CVD risk factors.
