摘要:OBJECTIVES: This study determined the prevalence of left-handedness and of switching hand preference among innately left-handed subjects. METHODS: Subjects of Swiss nationality (n = 1692), participating in a population-based survey in Geneva, Switzerland, completed a questionnaire on innate hand preference and current hand preference for writing. RESULTS: From 35 to 44 years of age to 65 to 74 years of age, the prevalence of innate left-handedness declined from 11.9% to 6.2% (trend P = .007). In these same age groups, the proportion of innately left-handed subjects who switched to the right hand for writing increased from 26.6% to 88.9% (trend P = .0001). CONCLUSIONS: Across generations, we found an increase in the prevalence of switching hand preference among innately left-handed subjects. This phenomenon could be explained by social and parental pressure to use the right hand.