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  • 标题:Could salicylates in food have contributed to the decline in cardiovascular disease mortality? A new hypothesis.
  • 本地全文:下载
  • 作者:L M Ingster ; M Feinleib
  • 期刊名称:American journal of public health
  • 印刷版ISSN:0090-0036
  • 出版年度:1997
  • 卷号:87
  • 期号:9
  • 页码:1554-1557
  • 出版社:American Public Health Association
  • 摘要:OBJECTIVES: The prophylactic effect of aspirin (at 80 mg/day) for the prevention of cardiovascular disease mortality has long been recognized. This study examined whether other salicylates are present in comparable quantities in the US food supply. METHODS: To estimate the order of magnitude for salicylates in the food supply, annual production data for selected synthetic salicylates were analyzed. RESULTS: Production figures for 1960 indicate exposure to salicylates of 250 mg/day per person, or 95 mg/day per person excluding aspirin. Trend data indicate a rise in the production of salicylates over time, reaching 341 mg/day per person, or 126 mg/day per person excluding aspirin, in 1970. CONCLUSIONS: The US ingestion of salicylates with aspirinlike properties may have increased to the point that many susceptible individuals have received a beneficial effect that has contributed to the decline in cardiovascular disease mortality.
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