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  • 标题:Isolation of Nabscessin C from Nocardia abscessus IFM 10029T and a Study on Biosynthetic Pathway for Nabscessins
  • 作者:Shoko Hara ; Yasumasa Hara ; Midori A. Arai
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2018
  • 卷号:66
  • 期号:10
  • 页码:976-982
  • DOI:10.1248/cpb.c18-00430
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A new aminocyclitol derivative, designated nabscessin C ( 1 ), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A ( 2 ) and B ( 3 ) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy- scyllo -inosamine pentaacetyl derivative ( 4 ) by hydrolysis and acetylation of 2 . The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.
  • 关键词:actinomycete;Nocardia;aminocyclitol;biosynthetic pathway
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